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PERIOMED VOICES 06 · LITERATURE LENS 02 · 31 OCTOBER 2026

Periodontitis and OPMDs
Under the Lens

Four papers. One connected question: can the periodontal environment influence malignant transformation?

LITERATURE LENS 02

Through the literature lens.

Martina Sansavini, DDS

Martina Sansavini, DDS

Italy

Host
Mohammed Hasan, BDS, BSc, MSc DPH

Mohammed Hasan, BDS, BSc, MSc DPH

Libya

Host

LITERATURE LENS 02 · CONVERSATION SYNOPSIS

Association, plausibility
and malignant transformation.

Martina Sansavini and Mohammed Hasan connect four papers addressing direct clinical associations, microbial patterns within oral potentially malignant disorders, evidence from oral cancer research and longitudinal human observations.

The conversation keeps three questions separate: whether periodontitis and OPMDs are associated, whether biologically plausible mechanisms connect them, and whether periodontitis independently modifies malignant transformation risk. The third question remains unanswered.

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PAPERS DISCUSSED

Read the four papers.

ACTA ODONTOLOGICA SCANDINAVICA · 2020Possible association of periodontal disease with oral cancer and oral potentially malignant disorders: a systematic reviewColonia-García and colleaguesJOURNAL OF STOMATOLOGY, ORAL AND MAXILLOFACIAL SURGERY · 2026Microbial dysbiosis in oral potentially malignant disorders: A systematic reviewKeerthika and colleaguesCANCER AND METASTASIS REVIEWS · 2025Demystifying the link between periodontitis and oral cancer: a systematic review integrating clinical, pre-clinical, and in vitro dataPigossi and colleaguesORAL DISEASES · 2025Oral Leukoplakia Microbiome Predicts the Degree of Dysplasia and is Shaped by Smoking and Tooth LossGalvin and colleagues